Diquafosol (sodium salt), CAS 211427-08-6

Formulation: A solid

Formal Name: uridine 5′-(pentahydrogen tetraphosphate), P′′′→5′-ester with uridine, tetrasodium salt

Purity: ≥95%

Formula Markup: C18H22N4O23P4 • 4Na

Formula Weight: 878,2

Shelf life (days): 1460

CAS Number: 211427-08-6

Notes: Diquafosol is an agonist of purinergic P2Y2 and P2Y4 receptors (EC50s = 0.1 and 0.4 µM, respectively, in calcium mobilization assays).{59982} It is selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = 20 µM). Ocular application of diquafosol (0.1 and 1% w/v) induces the release of mucin-like glycoproteins from rabbit conjunctival goblet cells, as well as reduces desiccation-induced corneal damage in a rabbit model of dry eye disease.{59983} Formulations containing diquafosol have been used in the treatment of dry eye disease.

• SKU: CAY33971-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33971-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK