Formulation: A crystalline solid
Formal Name: 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one, monohydrochloride
Purity: ≥98%
Formula Markup: C28H38N2O5 • HCl
Formula Weight: 519,1
Shelf life (days): 1460
CAS Number: 186097-54-1
Notes: DK-AH 269 blocks hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (IC50 = 0.62 µM in mouse sinoatrial node cells).{30118} DK-AH 269 slows heart rate by decreasing the spontaneous firing rate of the sinoatrial node in the heart.{33670} Using telemetric ECG recordings in mice, it reduced heart rate in a dose-dependent fashion with an ED50 of 1.2 mg/kg.{30118} DK-AH 269 also has proarrhythmic properties at concentrations higher than 5 mg/kg.{30118}