Formulation: A solid
Formal Name: 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole
Purity: ≥98%
Formula Markup: C13H9Cl2N3OS
Formula Weight: 326,2
Shelf life (days): 1460
CAS Number: 2253744-54-4
Notes: Dooku1 is an antagonist of yoda1-activated Piezo1 ion channels (IC50 = 1.3 µM in HEK293 cells expressing the human receptor).{67497} It is selective for Piezo1 activated by yoda1 (Item No. 21904) over constituitively active Piezo1, transient receptor potential vanilloid 4 (TRPV4), and transient receptor potential canonical 4 (TRPC4) at 10 µM. Dooku1 (10 µM) reduces the percentage of cells with yoda1-induced extracellular phosphatidylserine exposure in red blood cells (RBCs) isolated from patients with sickle cell anemia.{67498} Preincubation with dooku1 (10 µM) inhibits yoda1-induced relaxation of isolated mouse aortic rings.{67497}
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