Formulation: A solid
Formal Name: 8-cyclopentyl-3,9-dihydro-1,3-dipropyl-1H-purine-2,6-dione
Purity: ≥98%
Formula Markup: C16H24N4O2
Formula Weight: 304,4
Shelf life (days): 1460
CAS Number: 102146-07-6
Notes: DPCPX is an adenosine A1 receptor antagonist (Ki = 0.3 nM).{66536} It is selective for the adenosine A1 receptor over the adenosine A2 receptor (Ki = 340 nM). DPCPX (0.03 and 1 µM) increases the force of contractions in isolated guinea pig left auricles and inhibits decreases in contraction forces induced by the adenosine receptor agonists (–)-N6-phenylisopropyladenosine (PIA) or 5'-N-ethylcarboxamidoadenosine (NECA; Item No. 21420) in isolated guinea pig papillary muscles (pA2s = 9.3 and 9, respectively).{66537} It reverses cardiac arrest induced by adenosine, the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA; Item No. 21448), or the acetylcholine receptor agonist carbachol (carbamoylcholine; Item No. 14486) in isolated rat atrium.{66538} DPCPX (2 and 4 mg/kg) decreases immobility time in the forced swim test and tail suspension test in mice.{66539}
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