DPPE (fumarate), CAS 1185241-83-1

Formulation: A solid

Formal Name: N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine

Purity: ≥98%

Formula Markup: C19H25NO • C4H4O4

Formula Weight: 399,5

Shelf life (days): 1460

CAS Number: 1185241-83-1

Notes: DPPE is a ligand for the antiestrogen-binding site (AEBS; Ki = 55.6 nM in rat liver microsomes) and derivative of tamoxifen (Item No. 11629).{57916} It is selective for the AEBS over the estrogen receptor when used at a concentration of 10 µM. DPPE is cytotoxic to S10 and MCF-7 cells (IC50s = 7.5 and 12 µM) and inhibits antigen-induced histamine release in isolated rat mast cells (IC50 = 65-85 µM).{57919,57918} It decreases uterine size in immature oophorectomized rats in a dose-dependent manner.{57917} DPPE (4 mg/kg) protects bone marrow progenitor cells from cytotoxicity induced by doxorubicin (Item No. 15007) in mice.{57919}

• SKU: CAY35360-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35360-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe