Formulation: A solid
Formal Name: (βR),3-dihydroxy-L-tyrosine
Purity: ≥95%
Formula Markup: C9H11NO5
Formula Weight: 213,2
Shelf life (days): 1460
CAS Number: 23651-95-8
Notes: Droxidopa (L-DOPS) is a synthetic precursor and prodrug of the neurotransmitter norepinephrine.{40480} It is transformed into norepinephrine through the action of DOPA decarboxylase. L-DOPS increases norepinephrine levels in the rat heart following intraperitoneal administration and in the brain following intracerebroventricular administration at doses of 125 and 100 µg/animal, respectively. It increases arterial pressure and mesenteric arterial resistance in rats with ligated portal vein or biliary ducts when used at doses of 25-50 mg/kg.{40481} L-DOPS crosses the blood brain barrier, however, its effects can be blocked by the peripherally-restricted DOPA decarboxylase inhibitor carbidopa (Item No. 23783), indicating that the mechanism is peripheral.{40482,40481} Formulations containing droxidopa are used in the treatment of neurogenic orthostatic hypotension.
English
Deutsch
