Formulation: A crystalline solid
Formal Name: 3-[3-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methyl]amino]benzoyl]-1H-indole-1-butanoic acid
Purity: ≥95%
Formula Markup: C30H25Cl2N3O4
Formula Weight: 562,4
Shelf life (days): 730
CAS Number: 2446154-84-1
Notes: DS16570511 is an inhibitor of the mitochondrial calcium uniporter.{43404} It inhibits calcium uptake by mitochondria isolated from HEK293A cells, rat heart, and pig heart (IC50s = 0.86, 25, and 15 μM, respectively). DS16570511 inhibits fetal bovine serum-induced mitochondrial calcium influx as well as MCU- and MICU1-dependent increases in calcium influx in HEK293A cells (IC50 = 7 μM) but has no effect on mitochondrial membrane potential. Ex vivo, DS16570511 inhibits mitochondrial calcium overload induced by high calcium concentrations in isolated rat hearts. It also reversibly increases cardiac contractility without affecting heart rate.
English
Deutsch
