Formulation: A crystalline solid
Formal Name: 4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol
Purity: ≥98% (mixture of isomers)
Formula Markup: C25H27NO2
Formula Weight: 373,5
Shelf life (days): 1460
CAS Number: 110025-28-0
Notes: (E/Z)-Endoxifen is an active metabolite of tamoxifen (Item No. 13258) produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6.{29622,28212,29623} It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen.{29622} As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.{29622,28212,29623}