Formulation: A solid
Formal Name: L-histidyl-L-valyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-arginyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginyl-glycine
Purity: ≥98%
Formula Markup: C194H304N48O61
Formula Weight: 4284,8
Shelf life (days): 1460
CAS Number: 2459531-73-6
Notes: Ecnoglutide is a cAMP-biased peptide glucagon-like peptide 1 receptor (GLP-1R) agonist.{72518} It selectively induces cAMP accumulation over β-arrestin recruitment (EC50s = 0.018 and 1,300 nM, respectively) without inducing GLP-1R receptor internalization (EC50 = >10,000 nM) in cell-based assays using human GLP-1R. In vivo, ecnoglutide (0.15 mg/kg) reduces fasting and post-prandial blood glucose levels in db/db mice. It also reduces body weight and food intake in db/db mice when administered at a dose of 0.05 mg/kg.
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