Efonidipine, CAS 111011-63-3

Formulation: A crystalline solid

Formal Name: 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid, 2-[phenyl(phenylmethyl)amino]ethyl ester

Purity: ≥98%

Formula Markup: C34H38N3O7P

Formula Weight: 631,7

Shelf life (days): 730

CAS Number: 111011-63-3

Notes: Efonidipine is an inhibitor of L- and T-type voltage-gated calcium channels (Cavs).{60324} It inhibits Cav1.2a (IC50 = 1.8 nM for the hamster channel), an L-type Cav, and Cav3.2 (IC50 = 350 nM for the human channel), a T-type Cav. It also inhibits L- and T-type calcium channels and fetal bovine serum-induced hypertrophy in isolated mouse cardiomyocytes.{60325} Efonidipine (200 mg/kg) increases survival in a mouse model of acute myocardial infarction induced by ligation of the left coronary artery.{60326} Efonidipine is also an inhibitor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro; IC50 = 38.5 µM).{60327}

• SKU: CAY33114-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33114-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK