Formulation: A solid
Formal Name: 6R-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol, dihydrochloride
Purity: ≥98%
Formula Markup: C30H38N2O2 • 2HCl
Formula Weight: 531,6
Shelf life (days): 1460
CAS Number: 1349723-93-8
Notes: Elacestrant is a selective estrogen receptor degrader (SERD).{65822} It selectively binds to estrogen receptor α (ERα) over ERβ (IC50s = 48 and 870 nM, respectively) and reduces ERα levels in MCF-7 cells (EC50 = 0.6 nM). Elacestrant reduces MCF-7 proliferation induced by 17β-estradiol (E2; Item No. 10006315) (EC50 = 4 pM). In vivo, elacestrant (30 and 60 mg/kg) reduces E2-induced tumor growth in an MCF-7 mouse xenograft model. It increases survival in an MCF-7 intracranial mouse xenograft model. Elacestrant (0.1-3 mg/kg) protects against bone loss in ovariectomized rats.
English
Deutsch
