Formulation: A crystalline solid
Formal Name: 1,3,8-trihydroxy-6-methyl-9,10-anthracenedione
Purity: ≥98%
Formula Markup: C15H10O5
Formula Weight: 270,2
Shelf life (days): 1460
CAS Number: 518-82-1
Notes: Emodin is a naturally-occurring anthraquinone found in a variety of plants used in traditional Chinese medicine. Purified emodin has diverse effects, including the suppression of inflammation, dyslipidemia, and cancer.{21482,21479,21480} At a molecular level, emodin directly and selectively inhibits casein kinase II (IC50 = 0.89 μM).{21491,21488} Through this action, it inhibits the COP9 signalosome, causing the stabilization of the tumor suppressor p53.{21488} Moreover, emodin acts as a phytoestrogen, binding human estrogen receptors and blocking 17β-estradiol binding with Ki values of 0.77 and 1.5 μM for ERα and ERβ, respectively.{21490}
English
Deutsch
