EMPA, CAS 680590-49-2

Formulation: A solid

Formal Name: N-ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide

Purity: ≥98%

Formula Markup: C23H26N4O4S

Formula Weight: 454,5

Shelf life (days): 1460

CAS Number: 680590-49-2

Notes: EMPA is an orexin 2 receptor (OX2R) antagonist (Ki = 1.1 nM).{45690} It is selective for OX2R over OX1R (Ki = 900 nM). EMPA inhibits orexin-A- and orexin-B-induced calcium mobilization (IC50s = 8.8 and 7.9 nM, respectively) and increases orexin-A- and orexin-B-induced inositol phosphate accumulation (EC50s = 1.1 and 2.4 nM, respectively) in CHO(dHFr-) cells expressing recombinant human OX2R. It reduces spontaneous locomotor activity and orexin-B-induced hyperlocomotion in mice when administered at doses ranging between 10 and 300 mg/kg.

• SKU: CAY29446-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29446-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK