Formulation: A solid
Formal Name: (2S)-3-(4-cyanophenoxy-2,3,5,6-d4)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-propanamide
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C19H10D4F3N3O3
Formula Weight: 393,4
Shelf life (days): 1460
CAS Number: 1202044-20-9
Notes: Enobosarm-d4 is intended for use as an internal standard for the quantification of enobosarm by GC- or LC-MS. Enobosarm is a non-steroidal selective androgen receptor modulator (SARM; Ki = 0.0038 µM in a radioligand binding assay).{24834} It is a partial agonist of the androgen receptor (IC50 = 0.0364 µM in a transactivation assay) and inhibits the proliferation of 22Rv1, DU145, LNCaP, and VCaP prostate cancer cells (IC50s = 24.77, 44.55, 20.9, and 24.47 µM, respectively).{60912} Enobosarm (0.001 and 0.01 µM) inhibits lipogenesis in isolated rat adipocytes.{60913} It increases the weights of the prostate gland and seminal vesicles, markers of androgenic activity, and the levator ani muscle, a marker of anabolic activity, in castrated rats (ED50s = 0.12, 0.39, and 0.03 mg/day, respectively).{24834}
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