Formulation: A solid
Formal Name: L-leucyl-L-valyl-L-arginyl-L-tyrosyl-L-threonyl-L-lysyl-L-lysyl-L-valyl-L-prolyl-L-glutaminyl-L-valyl-L-seryl-L-threonyl-L-prolyl-L-threonyl-L-leucine, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C84H144N22O23 • XCF3COOH
Formula Weight: 1830,2
Shelf life (days): 1460
Notes: EPI-X4 is an endogenous peptide fragment corresponding to amino acids 408-423 of human serum albumin and an antagonist of chemokine (C-X-C motif) receptor 4 (CXCR4).{51524} It inhibits calcium mobilization and receptor internalization induced by chemokine (C-X-C motif) ligand 12 (CXCL12) in HEK293 cells expressing CXCR4 when used at concentrations ranging from 0.8 to 1,000 µM. EPI-X4 inhibits CXCL12-induced migration of Jurkat T cells and human CD34+ hematopoietic stem cells. In vivo, EPI-X4 (16 µmol/kg) reduces Cxcr4-dependent inflammatory cell airway infiltration in a mouse model of acute allergic airway hypereosinophilia. Urinary levels of EPI-X4 are increased and inversely correlated with glomerular filtration rate (GFR) in patients with chronic kidney disease.
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