Formulation: A solid
Formal Name: (10S)-1′-[(3,5-dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methyl-spiro[1H-imidazo[1,5-b][2]benzazepine-1,4′-piperidin]-3(2H)-one
Purity: ≥98%
Formula Markup: C30H39N3O3
Formula Weight: 489,7
Shelf life (days): 1460
CAS Number: 1155773-15-1
Notes: ER-819762 is an antagonist of the prostaglandin E2 (PGE2; Item No. 14010) receptor subtype EP4 (IC50 = 70 nM).{18146} It is selective for EP4 over EP1, EP2, and EP3 in a cAMP reporter assay at 10 µM. ER-819762 reduces differentiation of mouse helper T cells when used at concentrations ranging from 0.1 to 10 nM and decreases IL-23 secretion by mouse dendritic cells from 0.04 to 5 nM. It also reduces the levels of Marek's disease virus (MDV) in chicken embryonic fibroblasts (CEFs) when used at a concentration of 1 µM.{64845} Oral administration of ER-819762 (30 and 100 mg/kg) prevents and reverses paw swelling, edema, and inflammation in a mouse model of rheumatoid arthritis induced by glucose-6-phosphate isomerase (GPI).{18146}
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