Formulation: A solid
Formal Name: N,N-diethyl-α-methyl-10H-phenothiazine-10-ethanamine, monohydrochloride
Purity: ≥98%
Formula Markup: C19H24N2S • HCl
Formula Weight: 348,9
Shelf life (days): 1460
CAS Number: 1094-08-2
Notes: Ethopropazine is a butyrylcholinesterase (BChE) inhibitor (IC50 = 15.14 µM in human erythrocyte lysates).{53481} It is selective for BChE over acetylcholinesterase (AChE) at 500 µM. Ethopropazine also binds to rat forebrain and hindbrain membrane preparations (Kis = 3.1 and 7.2 nM, respectively), which are endogenously enriched in M1 and M2 muscarinic acetylcholine receptors, respectively.{53482} Ethopropazine (0.232 mg/kg) decreases the intensity and increases the latency of haloperidol-induced catalepsy, a model of extrapyramidal syndrome, in rats when used in combination with the adenosine A2A receptor antagonist ZM 241395 (Item No. 20447).{53483} It reduces thermal hyperalgesia in a rat model of neuropathic pain induced by sciatic nerve ligation when administered at doses of 20 and 30 mg/kg.{53484} Formulations containing ethopropazine were previously used in the treatment of Parkinson’s disease.
English
Deutsch
