Evocalcet, CAS 870964-67-3

Formulation: A crystalline solid

Formal Name: 4-[(3S)-3-[[(1R)-1-(1-naphthalenyl)ethyl]amino]-1-pyrrolidinyl]-benzeneacetic acid

Purity: ≥98%

Formula Markup: C24H26N2O2

Formula Weight: 374,5

Shelf life (days): 1460

CAS Number: 870964-67-3

Notes: Evocalcet is an agonist of the calcium-sensing receptor (CaSR).{62067} It induces intracellular calcium release in HEK293 cells expressing human CaSR (EC50 = 92.7 nM). Evocalcet reduces serum levels of parathyroid hormone (PTH) and calcium when administered at doses of 0.3 and 0.1 mg/kg, respectively, in non-nephrectomized and 5/6 nephrectomized rats. It also reduces serum levels of PTH without inducing emesis in marmosets when administered at doses of 0.3 and 0.5 mg/kg.

• SKU: CAY33346-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33346-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK