Exendin-4 (5-39) amide (trifluoroacetate salt)

Formulation: A solid

Purity: ≥95%

Formula Markup: C169H262N44O54S • XCF3COOH

Formula Weight: 3806,2

Shelf life (days): 1460

Notes: Exendin-4 (5-39) amide is a 34-amino acid synthetic peptide corresponding to residues 5-39 of exendin-4 (48-86) amide (Item No. 11096) and an antagonist of the glucagon-like peptide 1 (GLP-1) receptor (IC50 = 0.3 nM) that has roles in synaptic transmission.{67094} It decreases GLP-1-induced increases in intracellular cAMP levels in CHO/pancGLPR cells. Exendin-4 (5-39) amide (10 and 100 nM) increases extracellular glutamate reuptake in primary rat hippocampal astrocytes.{67093} In vivo, exendin-4 (5-39) amide increases excitatory amino acid transporter 2 (EAAT2) protein levels and decreases the field excitatory postsynaptic potential decay time in the rat dentate gyrus when administered intracerebroventricularly.

• SKU: CAY35847-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35847-5
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: Reinstoffe