Formulation: A solid
Formal Name: 3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)-propanimidamide1-13C-2,3,3-d3
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C7[13C]H12D3N7O2S3
Formula Weight: 341,5
Shelf life (days): 1460
CAS Number: 2744683-81-4
Notes: Famotidine-13C-d3 is intended for use as an internal standard for the quantification of famotidine (Item No. 23828) by GC- or LC-MS. Famotidine is a histamine H2 receptor antagonist with a Ki value of 12 nM in fractionated guinea pig cerebral cortex membranes.{36463} It is selective for H2 over H1 and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex).{23214} Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells (IC50 = 0.6 µM).{17620} It also suppresses histamine-induced gastric acid secretion in dogs when administered orally and in anesthetized rats when administered intraduodenally (ID50s = 10 and 400 µg/kg, respectively).{17620} Formulations containing famotidine have been used in the treatment of ulcers, gastroesophageal reflux disease (GERD), and heartburn, as well as to decrease the risk of gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs).
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