Formulation: A solid
Formal Name: 2-[4-(4-chlorobenzoyl)phenoxy]-2-(methyl-d3)-propanoic-3,3,3-d3 acid, 1-methylethyl ester
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C20H15ClD6O4
Formula Weight: 366,9
Shelf life (days): 1460
CAS Number: 1092484-56-4
Notes: Fenofibrate-d6 is intended for use as an internal standard for the quantification of fenofibrate (Item No. 10005368) by GC- or LC-MS. Fenofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 values of 18 and 30 μM for mouse and human receptors, respectively, in a transactivation assay.{10670} It is selective for PPARα over PPARγ (EC50s = 300 and 200 μM for mouse and human receptors, respectively) and lacks activity at mouse and human PPARδ at a concentration of 100 μM. In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner.{43262} It decreases glomerular and tubular atrophy and necrosis induced by cisplatin (Item No. 13119) in rat kidney when administered at a dose of 100 mg/kg.{43263} Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung of Tsumura Suzuki obese diabetic (TSOD) mice.{43264}
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