FG-7142, CAS 78538-74-6

Formulation: A crystalline solid

Formal Name: N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide

Purity: ≥98%

Formula Markup: C13H11N3O

Formula Weight: 225,2

Shelf life (days): 1460

CAS Number: 78538-74-6

Notes: FG-7142 is a benzodiazepine receptor ligand with anxiogenic and proconvulsant properties.{48712} It increases benzodiazepine receptor ligand binding and GABA-dependent chloride uptake in primary chick cerebral cortical neurons when used at a concentration of 1 μM. FG-7142 (5 mg/kg) decreases pinning of the other animal and increases avoiding behavior in rats, an effect that can be prevented by the benzodiazepine receptor antagonist Ro 15-1788 (flumazenil; Item No. 14252).{48713} It reduces the infused pentylenetetrazol (PTZ; Item No. 18682) seizure threshold and induces generalized seizures in mice when administered at doses of 10 and 40 mg/kg, respectively.{48714} FG-7142 (3.75, 7.5, and 15 mg/kg, i.p.) also decreases food and water intake, eating rate, and time spent in the open arms of the elevated plus maze in female rats.{48715}

• SKU: CAY29183-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29183-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK