Finerenone, CAS 1050477-31-0

Formulation: A solid

Formal Name: (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide

Purity: ≥98%

Formula Markup: C21H22N4O3

Formula Weight: 378,4

Shelf life (days): 1460

CAS Number: 1050477-31-0

Notes: Finerenone is a non-steroidal mineralocorticoid receptor antagonist (IC50 = 18 nM).{68137} It is selective for the mineralocorticoid receptor over glucocorticoid, progesterone, and androgen receptors (IC50s = >10,000 nM for all), as well as L-type calcium channels (IC50 = >10,000 nM). Finerenone (3 mg/kg) reduces renal vasculopathy, fibrosis, and tubular degeneration, as well as cardiac fibrosis, in a rat model of hypertension-induced end-organ damage.{68138} It also increases exercise capacity and prevents diastolic dysfunction in ovariectomized mice.{68139}

• SKU: CAY36086-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36086-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK
• Application: Reinstoffe