Formulation: A solid
Formal Name: 1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl-1,1,2,2-d4]-2H-benzimidazol-2-one, monohydrochloride
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C20H17D4F3N4O • HCl
Formula Weight: 430,9
Shelf life (days): 1460
CAS Number: 2748630-46-6
Notes: Flibanserin-d4 is intended for use as an internal standard for the quantification of flibanserin (Item No. 19203) by GC- or LC-MS. Flibanserin is a full agonist of the serotonin 5-HT1A receptor and an antagonist of 5-HT2A (Kis = 1 and 49 nM, respectively).{31001} It also binds to dopamine D4 receptors with Ki values ranging from 4-24 nM, but demonstrates no affinity for the other 5-HT subtypes or other neurotransmitter receptors.{31001} In vitro, flibanserin has been shown to reduce forskolin-stimulated cAMP formation in cells and rat tissues and to antagonize the accumulation of phosphatidyl inositol turnover induced by 5-HT in the mouse cortex.{31001} At 10 mg/kg, flibanserin can reduce serotonin in the prefrontal cortex and dorsal raphe of conscious rats while increasing extracellular noradrenaline and dopamine.{31001}
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