Formulation: A crystalline solid
Formal Name: 2-[[3-(trifluoromethyl)phenyl]amino]-benzoic acid
Purity: ≥98%
Formula Markup: C14H10F3NO2
Formula Weight: 281,2
Shelf life (days): 1460
CAS Number: 530-78-9
Notes: Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively).{8427} Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner.{8510} It inhibits calcium influx induced by fMLP (fMLF; Item No. 21495) or A23187 (Item No. 11016) in human polymorphonuclear leukocytes (PMN) with IC50 values of 29 and 14 µM, respectively.{1819} Flufenamic acid also activates various ion channels, including transient receptor potential canonical 6 (TRPC6) and large-conductance calcium-activated potassium channel (KCa1.1).{60389} It also inhibits various ion channels, including TRPC3 and cystic fibrosis transmembrane conductance regulator (CFTR). Flufenamic acid (20 mg/kg) reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice infected with the El Tor variant of V. cholerae.{60390}
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