Formulation: A solid
Formal Name: N-[2-amino-6-[[(4-fluorophenyl-d4)methyl]amino]-3-pyridinyl]-carbamic acid, ethyl ester, monohydrochloride
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C15H13D4FN4O2 • HCl
Formula Weight: 344,8
Shelf life (days): 1460
CAS Number: 1324717-75-0
Notes: Flupirtine-d4 is intended for use as an internal standard for the quantification of flupirtine (Item No. 16674) by GC- or LC-MS. Flupirtine is an activator of voltage-gated potassium channel 7 (Kv7/KCNQ).{45470,45471,45472} It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT+) mice.{45471} Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension. It increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy when administered at a dose of 10 mg/kg and increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine.{45472} Flupirtine also indirectly antagonizes NMDA receptors via its effects on potassium channels.{45470,45473}
English
Deutsch
