Formulation: A solution in methyl acetate
Formal Name: 9α,11α,15R-trihydroxy-16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C23H25D4F3O6
Formula Weight: 462,5
Shelf life (days): 730
Notes: Fluprostenol-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of fluprostenol by (Item No. 16768) GC- or LC-MS. Fluprostenol is a metabolically stable analog of prostaglandin F2α (PGF2α) with potent FP receptor agonist activity.{1182,1374} It inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively.{1182,1374} Fluprostenol is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 g/kg to terminate pregnancy.{3160} It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 value of 3-10 x 10−11 M.{4404}
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