Formulation: A solution in methyl acetate
Formal Name: 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5Z-heptenoic-d4 acid, 1-methylethyl ester
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C26H31D4F3O6
Formula Weight: 504,6
Shelf life (days): 730
Notes: Fluprostenol isopropyl ester-d4 is intended for use as an internal standard for the quantification of fluprostenol isopropyl ester (Item No. 16769) by GC- or LC-MS. Fluprostenol isopropyl ester is an analog of prostaglandin F2α (PGF2α; Item Nos. 16010 / 16020) and an isopropyl ester prodrug form of (+)-fluprostenol (Item No. 16768).{8839,9613} Fluprostenol isopropyl ester is an FP receptor agonist, inducing phosphoinositide turnover in HEK293 cells expressing the human ocular FP receptor with an EC50 value of 40.2 nM.{11931} Topical application of fluprostenol isopropyl ester (0.01, 0.03, and 0.1 μg) induces miosis in conscious cats in a dose-dependent manner.{9613} It reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension when administered topically at doses of 0.1 and 0.3 μg twice per day. Formulations containing fluprostenol isopropyl ester have been used in the treatment of open-angle glaucoma and ocular hypertension.
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