Formulation: A crystalline solid
Formal Name: 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-benzamide
Purity: ≥98%
Formula Markup: C22H17Cl2F6N3O3
Formula Weight: 556,3
Shelf life (days): 1460
CAS Number: 864731-61-3
Notes: Fluralaner is an isoxazoline ectoparasiticide.{36084,36085} It potently and selectively inhibits binding of the GABA receptor channel blocker [3H]4'-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) to housefly head membranes, with an IC50 value of 455 pM as compared to an IC50 value of >10 μM for rat brain membranes.{36084} Fluralaner blocks GABA- and glutamate-induced chloride currents in Xenopus oocytes expressing housefly MdGBCl or MdGluCl channels (IC50s = 5.32 and 79.9 nM, respectively) but has no effect on rat GABA Cl channels (IC50 = >30,000 nM). It has insecticidal and acaricidal activity against C. felis, S. calcitrans, L. cuprina, A. aegypti, R. microplus, R. sanguineus, and O. moubata at concentrations of 0.0000012 to 1 ppm.{36085} Formulations containing fluralaner have been used in the prevention and treatment of parasitic infections in veterinary medicine.
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