Formulation: A solid
Formal Name: rel-N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-(methoxy-13C-d3)phenyl)-1-methylethyl]amino]ethyl]phenyl]-formamide, 2E-butenedioate (2:1)
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C18[13C]H21D3N2O4 • 1/2C4H4O4
Formula Weight: 406,5
Shelf life (days): 1460
Notes: Formoterol-13C-d3 is intended for use as an internal standard for the quantification of formoterol (Item No. 15584) by GC- or LC-MS. Formoterol is a selective agonist of the β2-adrenergic receptor (β2-AR; Kis = 7.58 and 2,630 nM for β2- and β1-ARs, respectively).{25444} It is selective for β-ARs in isolated guinea pig trachea over those in atrial tissue (pD2s = 9.29 and 6.98, respectively) and has a long duration of action.{36701,25444} Aerosolized formoterol (10 µg/ml, inhaled) prevents the late asthmatic response and eosinophil and macrophage infiltration in bronchoalveolar lavage fluid (BALF), and as well as reduces bronchial reactivity in a guinea pig model of allergic asthma induced by ovalbumin.{36702} Formulations containing formoterol have been used, alone and in combination with other compounds, in the treatment of chronic obstructive pulmonary disease and asthma.{25441,25443,25440}
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