Formulation: A crystalline solid
Formal Name: 2-(3,4-dihydroxyphenyl)ethyl O-D-apio-β-D-furanosyl-(1→6)-O-[6-deoxy-α-L-mannopyranosyl-(1→3)]-β-D-glucopyranoside, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
Purity: ≥95%
Formula Markup: C34H44O19
Formula Weight: 756,7
Shelf life (days): 1460
CAS Number: 81525-13-5
Notes: Forsythoside B is phenylpropanoid glycoside that has been found in M. alysson and has diverse biological activities.{48654,48655,48656,48658,48657} It scavenges PTIO (Item No. 14982), ABTS (Item No. 27317), O2-, and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell-free assays (IC50s = 125.5, 14, 262.6, and 8.7 μM, respectively).{48655} Forsythoside B (10-100 μg/ml) reduces hydrogen peroxide-induced cytotoxicity in bone marrow-derived mesenchymal stem cells (bmMSCs). It inhibits 2-aminoethoxydiphenyl borate-induced activation of transient receptor potential vanilloid 3 (TRPV3; IC50 = 6.7 μM in HEK293 cells expressing the human receptor) and reduces carvacrol-induced scratching behavior in mice.{48656} Forsythoside B (40 mg/kg) reduces serum levels of TNF-α, IL-6, IL-10, endotoxin, and triggering receptor expressed on myeloid cells 1 (TREM-1) and increases survival in a rat model of cecal ligation and puncture-induced sepsis.{48658} It also reduces infarct size and brain edema in a rat model of cerebral ischemia and reperfusion injury induced by middle cerebral artery occlusion.{48657}
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