Formulation: A crystalline solid
Formal Name: 4-chloro-N-cyclohexyl-N-(phenylmethyl)-benzamide
Purity: ≥98%
Formula Markup: C20H22ClNO
Formula Weight: 327,9
Shelf life (days): 1460
CAS Number: 945714-67-0
Notes: FPS-ZM1 is a high-affinity inhibitor of the receptor for advanced glycation end products (RAGE; Ki = 25 nM).{21041} It blocks the binding of amyloid β (Aβ) protein to RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells.{21041} FPS-ZM1 is functional in mice when administered intraperitoneally and penetrates the blood-brain barrier (BBB), inhibiting β-secretase activity, Aβ production, microglia activation, and neuroinflammation.{21041,33327} FPS-ZM1 is used to elucidate the role of RAGE-mediated signaling in diverse physiological processes in vivo, including cancer tumor growth, angiogenesis, and metastasis, as well as BBB damage, edema, and inflammation after intracerebral hemorrhage.{33328,33329}
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