Fz7-21 (trifluoroacetate salt)

Formulation: A solid

Formal Name: N-acetyl-L-leucyl-L-prolyl-L-seryl-L-α-aspartyl-L-α-aspartyl-L-leucyl-L-α-glutamyl-L-phenylalanyl-L-tryptophyl-L-cysteinyl-L-histidyl-L-valyl-L-methionyl-L-tyrosynamide, trifluoroacetate salt

Purity: ≥98%

Formula Markup: C83H114N18O23S2 • XCF3COOH

Formula Weight: 1796

Shelf life (days): 1460

Notes: Fz7-21 is a peptide antagonist of the frizzled family G protein-coupled receptor 7 (FZD7; IC50 = 100 nM).{72158} It inhibits Wnt3a-induced β-catenin signaling in a reporter assay using HEK293 cells. Fz7-21 (100 µM) reduces the number of cells positive for leucine-rich α-2-glycoprotein 5 (Lrg5), a marker of intestinal stem cells, and the mRNA encoding achaete-scute homolog 2 (Ash-2) and Axin2 and increases mRNA encoding mucin 2 (Muc2) in primary mouse intestinal organoids.

• SKU: CAY36922-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36922-5
• Package Unit: 5 mg
• Quantity Unit: STK