Formulation: A solid
Formal Name: N-D-γ-glutamyl-glycine, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C7H12N2O5 • CF3COOH
Formula Weight: 318,2
Shelf life (days): 1460
CAS Number: 71822-19-0
Notes: γ-D-Glutamylglycine (γ-DGG) is an antagonist of the excitatory amino acids NMDA (Item No. 14581), quisqualate, kainate, and glutamate.{67019} It decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat hippocampal slices when used at a concentration of 200 mM. Subdural administration of γ-DGG inhibits NMDA-, kainate-, or quisqualate-induced paw biting, indicating antinociceptive activity, in mice (EC50s = 63, 9.5, and 31 µM, respectively).{67020} γ-DGG reduces sound-induced wild running and inhibits the clonic and tonic phases of sound-induced seizures in DBA/2 mice (ED50s = 0.058, 0.046, and 0.054 µmol, i.c.v., respectively).{67021}
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