Formulation: A crystalline solid
Formal Name: 1α,2α,3β,4α,5α,6β-hexachloro-cyclohexane
Purity: ≥98%
Formula Markup: C6H6Cl6
Formula Weight: 290,8
Shelf life (days): 1460
CAS Number: 58-89-9
Notes: γ-Lindane is an organochloro insecticide that is an antagonist of GABAA receptors.{37358} It inhibits GABA-stimulated chloride uptake by membrane vesicles isolated from rat cerebral cortex (IC50 = 68 μM). It binds selectively to insect GABAA receptors over mammalian GABAA receptors in membrane preparations (IC50s = 1, 12, 505, 833, and 150-1, 675 nM for fruit fly, house fly, human, mouse, and rat, respectively).{37359,37360} It binds to a human recombinant β3 homooligomer with similar selectivity as α1β3γ2-containing receptors, indicating that the binding site for γ-lindane on GABAA receptors is located on the β3 subunit (IC50s = 0.90, 21, and 306 nM for β3, α1β3γ2, and the native receptor, respectively).{37361} γ-Lindane blocks GABA- and glutamate-induced current responses in American cockroach neurons (IC50s = 1.74 and 148 nM, respectively).{37362} It is toxic to mice and adult house flies (LD50s = 40 and 5.5 mg/kg, respectively) and also kills head lice in vitro and inhibits hatching.{37361,37363}
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