γ1-MSH (human, mouse, rat, bovine) (acetate)

Formulation: A solid

Formal Name: (3S,6S,9S,12S,15S,21S,24S,27S)-15-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-27-amino-3-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)carbamoyl)-12-benzyl-9-(3-guanidinopropyl)-28-(4-hydroxyphenyl)-24-isopropyl-21-(2-(methylthio)ethyl)-5,8,11,14,17,20,23,26-octaoxo-4,7,10,13,16,19,22,25-octaazaoctacosanoic acid, acetate

Purity: ≥95%

Formula Markup: C72H97N21O14S • XC2H4O2

Formula Weight: 1512,8

Shelf life (days): 1460

Notes: γ1-Melanocyte-stimulating hormone (γ1-MSH) is a peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland.{69889} It selectively binds to melanocortin receptor 1 (MC1R) and MC3R over MC4R and MC5R (Kis = 0.025, 0.063, >100, and >100 µM, respectively, in insect cells expressing the human receptors) but also binds to opioid receptors in rat brain tissue homogenates (IC50 = 5.9 µM).{69890,69891} γ1-MSH (10 µM) inhibits contractions induced by the neuropeptide FMRF-amide in isolated M. edulis catch muscle.{69892} Intracisternal administration of γ1-MSH (0.3 nmol/animal) increases the latency to tail flick in the tail-flick test and inhibits haloperidol-induced catalepsy in mice.{69893} γ1-MSH (0.01 nmol/animal) also inhibits LPS-induced nitric oxide (NO) release in mouse forebrain in vivo.{69890}

• SKU: CAY42252-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42252-5
• Package Unit: 5 mg
• Quantity Unit: STK