Formulation: A solid
Formal Name: glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-histidyl-L-alanyl-L-valylglycyl-L-asparaginyl-L-histidyl-L-arginyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-lysyl-L-asparaginylglycyl-L-leucyl-L-threonyl-L-serine, acetate
Purity: ≥98%
Formula Markup: C139H210N42O43 • XC2H4O2
Formula Weight: 3157,4
Shelf life (days): 1460
Notes: Human galanin is a 30-amino acid neuropeptide and galanin (GAL) receptor agonist.{57418,57419,57420,57421} It inhibits forskolin-induced cAMP production in HEK293E cells expressing recombinant human GAL1 receptors (EC50 = 0.031 nM) and stimulates inositol phosphate accumulation in CHO cells expressing recombinant human GAL2 receptors (EC50 = 12.3 nM).{57418,57419} Human galanin induces contractions in isolated rat longitudinal fundus strips with an EC50 value of 13.8 nM.{57420} Intrathecal administration of human galanin (3, 10, and 30 nmol/animal) reduces paw licking and flinching in the second, but not first, phase of the formalin test in rats.{57421}
English
Deutsch
