Formulation: A solid
Formal Name: 5-(2,5-dimethylphenoxy)-2,2-di(methyl-d3)-pentanoic acid
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C15H16D6O3
Formula Weight: 256,4
Shelf life (days): 1460
CAS Number: 1184986-45-5
Notes: Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil (Item No. 14835) by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated receptor α (PPARα) and PPARγ agonist (EC50s = 193.3 and 147.8 µM, respectively, in transactivation assays).{23621} In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia.{54664} Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice.{54665} Formulations containing gemfibrozil have been used in the treatment of high cholesterol.
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