Formulation: A lyophilized powder
Formal Name: glycyl-L-seryl-O-(1-oxooctyl)-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine, 2,2,2-trifluoroacetate
Purity: ≥95%
Formula Markup: C147H245N45O42 • XCF3COOH
Formula Weight: 3314,8
Shelf life (days): 1460
CAS Number: 659739-25-0
Notes: Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).{7811,37391} It increases intracellular calcium in CHO cells expressing rat GHS-R (EC50 = 2.5 nM) and induces GH release from primary rat pituitary cells (EC50 = 2.1 nM).{7811} Ghrelin (10 nM) also reduces glucose-, arginine-, and carbachol-induced insulin release and arginine-induced somatostatin release from perfused rat pancreas.{37392} It increases GH plasma levels in anesthetized rats, but does not affect follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, thyroid-stimulating hormone (TSH), or adrenocorticotropic hormone (ACTH) levels when administered at a dose of 10 μg per animal.{7811} Ghrelin increases gastric motility in rats in a dose-dependent manner when administered intracranially into the lateral septum and increases food intake and body weight when administered intracerebroventricularly at a dose of 1 μg per animal.{37393,37394}
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