Formulation: A crystalline solid
Formal Name: (3β,12β)-20-[(6-O-α-L-arabinofuranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
Purity: ≥98%
Formula Markup: C53H90O22
Formula Weight: 1079,3
Shelf life (days): 730
CAS Number: 11021-14-0
Notes: Ginsenoside Rc is a saponin that has been found in P. ginseng and has diverse biological activities, including antioxidant, anti-inflammatory, and nootropic properties.{45626,45627,45628} It prevents UVB-induced increases in the levels of reactive oxygen species (ROS) in HaCaT keratinocytes by 34.3, 54.4, and 65.4% when used at concentrations of 5, 12, and 30 µM, respectively.{45626} Ginsenoside Rc (40 µg/ml) reduces increases in the expression of Tnf, Il1b, and Ifnb1 induced by LPS in RAW 264.7 cells.{45627} It reduces gastric ulcer and joint lesion indices in mouse models of HCl/ethanol-induced gastritis and collagen-induced arthritis, respectively, as well as reduces increased serum levels of aspartate aminotransferase (AST) induced by LPS/D-galactosamine in a mouse model of hepatitis, when administered at a dose of 20 mg/kg. Ginsenoside Rc increases GABA-induced inward current in Xenopus oocytes expressing recombinant human α1β1ɣ2S subunit-containing GABAA receptors with an EC50 value of 53.2 µM.{45628}
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