Formulation: A solid
Formal Name: (3β,5β,16β)-3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14,16-dihydroxy-card-20(22)-enolide
Purity: ≥98%
Formula Markup: C41H64O14
Formula Weight: 780,9
Shelf life (days): 1460
CAS Number: 4562-36-1
Notes: Gitoxin is a cardiac glycoside originally found in Digitalis that has cardiotonic and antiarrhythmic activities.{67682,67683,67684} It inhibits Na+/K+-ATPase in an isoform-specific biphasic manner with IC50 values of 0.298 and 410 µM for the high- and low affinity human erythrocyte isoenzymes, respectively, and 1.18 and 28.5 µM for the high- and low affinity porcine cerebral cortex isoenzymes, respectively.{67683} Gitoxin increases contractility and rhythmicity in isolated guinea pig heart in a concentration-dependent manner.{67684} It is also a degradation product of the cardiac glycoside digoxin (Item No. 22266).{67685}
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