GLP-1R Agonist DMB, CAS 281209-71-0

Formulation: A crystalline solid

Formal Name: 6,7-dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-2-quinoxalinamine

Purity: ≥98%

Formula Markup: C13H15Cl2N3O2S

Formula Weight: 348,2

Shelf life (days): 1460

CAS Number: 281209-71-0

Notes: GLP-1R agonist DMB is an agonist of glucagon-like peptide 1 receptor (GLP-1R; KB = 26.3 nM for the recombinant human receptor).{46660} It inhibits forskolin-induced cAMP accumulation in BHK cells expressing the recombinant human receptor with an EC50 value of 101 nM.{46661} GLP-1R (100 and 1,000 nM) increases insulin levels induced by D-(+)-glucose (Item No. 23733) in pancreatic islets isolated from wild-type, but not Glp1r knockout, mice. It reduces fasting plasma glucose levels in mice when administered at a dose of 5 µmol/kg.{46662}

• SKU: CAY29678-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29678-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK