GLPG2938, CAS 2130996-00-6

Formulation: A solid

Formal Name: N-[2-ethoxy-6-(trifluoromethyl)-4-pyridinyl]-N′-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3-pyridazinyl]methyl]-urea

Purity: ≥98%

Formula Markup: C20H19F6N7O2

Formula Weight: 503,4

Shelf life (days): 1460

CAS Number: 2130996-00-6

Notes: GLPG2938 is sphingosine-1-phosphate receptor 2 (S1P2) antagonist.{63360} It inhibits S1P-induced calcium flux in CHO cells overexpressing human S1P2 (IC50 = 8.8 nM). GLPG2938 inhibits S1P-induced IL-8 release in HFL1 cells (IC50 = 0.6 nM) and S1P-induced contraction of human lung fibroblasts. In vivo, GLPG2938 (3, 10, and 30 mg/kg) prevents epithelial damage and pulmonary fibrosis, structural distortion, and inflammation in a mouse model of bleomycin-induced pulmonary fibrosis.

• SKU: CAY34318-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34318-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK