Glyburide-d3, CAS 1219803-02-7

Formulation: A solid

Formal Name: 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-(methoxy-d3)-benzamide

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C23H25ClD3N3O5S

Formula Weight: 497

Shelf life (days): 1460

CAS Number: 1219803-02-7

Notes: Glyburide-d3 is intended for use as an internal standard for the quantification of glyburide (Item No. 15009) by GC- or LC-MS. Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM).{22674} It binds to microsomes derived from RINm5F pancreatic β-cells (Kd = 0.3 nM) and inhibits 86Rb+ efflux from intact RINm5 cells with a half-maximal inhibition (K0.5) value of 0.06 nM.{22672} Glyburide (5 mg/kg) reduces blood glucose levels and increases the activity of hepatic glutathione-S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH) in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{43282} It inhibits ATP-induced increases in caspase-1 activation and IL-1β and IL-18 secretion in a concentration-dependent manner in LPS-primed bone marrow-derived macrophages (BMDMs).{22671} Glyburide (80 mg/ml) also reduces lesion growth in mice infected with L. mexicana.{22673} Formulations containing glyburide have been used in the treatment of type 2 diabetes.

• SKU: CAY25740-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 25740-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: GC-MS, LC-MS, Isotopenmarkierung