Formulation: A crystalline solid
Formal Name: N-(4-methyl-2-quinazolinyl)-guanidine, monohydrochloride
Purity: ≥95%
Formula Markup: C10H11N5 • HCl
Formula Weight: 237,7
Shelf life (days): 1460
CAS Number: 5361-15-9
Notes: GMQ is an activator of acid-sensing ion channel 3 (ASIC3).{54008} It evokes rapid inward currents with little desensitization in CHO cells expressing ASIC3 (EC50 = 67 µM at neutral pH). It is also an inhibitor of the GABAA receptor (IC50 = 0.39 µM in primary rat hippocampal neurons).{54009} GMQ has stimulatory effects on large-conductance calcium-activated potassium (KCa1.1/BKCa) channels in GH3 rat pituitary cells and on non-selective cation currents in Rolf B1.T olfactory sensory neurons.{54010} It increases paw licking time in Asic3+/+ and, to a lesser extent, Asic3-/- mice when administered at a dose of 100 µM, an effect that can be blocked by the ASIC inhibitor amiloride (Item No. 14409).{54008}
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