Formulation: A solid
Formal Name: N-cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methyl-indeno[1,2-c]pyrazole-3-carboxamide
Purity: ≥98%
Formula Markup: C24H23Cl2N3O
Formula Weight: 440,4
Shelf life (days): 1460
CAS Number: 919077-81-9
Notes: GP 2a is a cannabinoid 2 (CB2) receptor agonist (Ki = 7.6 nM for the mouse receptor).{67742} It is selective for CB2 receptors over CB1 receptors (Ki = 900 nM for the mouse receptor). GP 2a (5 to 100 nM) induces the CB2 receptor-dependent phosphorylation of ERK1/2 in HL-60 leukemia promyeloblasts. In vivo, GP 2a (4 mg/kg per day) increases the mechanical threshold force to paw withdrawal and the latency to paw withdrawal from a radiant heat stimulus in a mouse model of neuropathic pain induced by spared nerve injury (SNI).{67743} GP 2a inhibits SNI-induced increases in the number of activated spinal microglia and spinal astrocytes in the same mice.
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