GR127935 (hydrochloride), CAS 148642-42-6

Formulation: A crystalline solid

Formal Name: N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1′-biphenyl]-4-carboxamide, monohydrochloride

Purity: ≥98%

Formula Markup: C29H31N5O3 • HCl

Formula Weight: 534,1

Shelf life (days): 1460

CAS Number: 148642-42-6

Notes: GR127935 is an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1B, 5-HT1Dα, and 5-HT1Dβ (IC50s = 3.16, 1.26, and 0.13 nM, respectively).{53337} It is selective for the 5-HT1B and 5-HT1D receptors over other 5-HT receptors (IC50s = 39.81->10,000 nM in radioligand binding assays). GR127935 increases extracellular 5-HT levels in the guinea pig frontal cortex and prevents increases in 5-HT in rat frontal cortex induced by the selective serotonin reuptake inhibitor paroxetine (Item No. 14998).{53338} It enhances memory consolidation in an autoshaping learning task in rats when administered post-training at a dose of 10 mg/kg.{53339} It has been used to elucidate the 5-HT receptor subtypes involved in the anti-inflammatory activity of sumatriptan (Item No. 14600) following myocardial ischemia-reperfusion injury and testicular torsion/detorsion.{53340,53341}

• SKU: CAY29651-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29651-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK