GSK1292263, CAS 1032823-75-8

Formulation: A crystalline solid

Formal Name: 5-[[1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl]methoxy]-2-[4-(methylsulfonyl)phenyl]-pyridine

Purity: ≥98%

Formula Markup: C23H28N4O4S

Formula Weight: 456,6

Shelf life (days): 1460

CAS Number: 1032823-75-8

Notes: GSK1292263 is an agonist of G protein-coupled receptor 119 (GPR119; EC50 = 43.9 nM in CHO-K1 cells expressing human receptors).{47194} It inhibits increases in sterol regulatory element binding protein-1 (SREBP-1) levels induced by the LXR agonist T0901317 and increases activation of AMPK in HepG2 cells in a concentration-dependent manner.{36741} GSK1292263 also inhibits breast cancer resistant protein (BCRP) and organic anion transporting polypeptide 1B1 (OATP1B1) by 52 and 40%, respectively, when used at a concentration of 3 μM.{47195}

• SKU: CAY26181-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 26181-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK