Formulation: A crystalline solid
Formal Name: 2-chloro-5-nitrobenzanilide
Purity: ≥98%
Formula Markup: C13H9ClN2O3
Formula Weight: 276,7
Shelf life (days): 730
CAS Number: 22978-25-2
Notes: The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo.{7575,8224} Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class.{8241} There are many PPARγ agonists, including 15-deoxy-Δ12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived.{8461,8930} However, only a few antagonists have been reported.{8953} GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM.{8953} It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.{9318}
English
Deutsch
