GX-674, CAS 1432913-36-4

Formulation: A solid

Formal Name: 4-[2-(2-amino-1H-benzimidazol-6-yl)-4-chlorophenoxy]-2,5-difluoro-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide

Purity: ≥95%

Formula Markup: C21H13ClF2N6O3S2

Formula Weight: 534,9

Shelf life (days): 1460

CAS Number: 1432913-36-4

Notes: GX-674 is a state-dependent inhibitor of voltage-gated sodium channel 1.7 (Nav1.7).{72124} It selectively inhibits Nav1.7 in HEK293 cells in a patch-clamp assay at -40 mV over -120 mV, voltages that correspond to steady-state inactivation and the resting closed state of the channel (IC50s = 0.1 and 240 nM, respectively). GX-674 is also selective for Nav1.7 over Nav1.1, Nav1.3-1.5, and Nav1.8 but does inhibit Nav1.2 and, to a lesser extent, Nav1.6.

• SKU: CAY39677-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39677-25
• Package Unit: 25 mg
• Quantity Unit: STK